Ryan Bogdan’s research examines how genomic variation and environmental experience contribute to individual differences in neural phenotypes, behavior, and psychopathology. He is particularly interested in understanding how differences emerge in reward and threat processing, as well as stress responsiveness, and the role of these factors in the development of psychopathology (e.g., depression, anxiety, substance use disorders). Within this work, is a focus on how early life adversity and later stress exposure shape risk for mental and physical health outcomes through gene expression, stress hormone and inflammation signaling, as well as brain structure and function. He uses a variety of methods including molecular genetics, GWAS, fMRI, EEG/ERP, pharmacologic challenge, twin studies, behavioral assessment, endocrine and inflammation assays, and self-report in both healthy and clinical populations across the lifespan.
- Bogdan R, Hyde LW & Hariri AR. (in press). A neurogenetics approach to understanding individual differences in brain, behavior and risk for psychopathology. Molecular Psychiatry.
- Bogdan R & Hariri AR. (2012). Neural embedding of stress reactivity. Nature Neuroscience, 15, 1605-1607.
- White MG, Bogdan R, Fisher PM, Muñoz K, Williamson DE & Hariri AR. (2012). FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. Genes, Brain and Behavior, 11, 869-878.
- Bogdan R, Williamson DE & Hariri AR. (2012). Mineralocorticoid recceptor iso/val genotype (rs5522) moderates the association between priori childhood emotional neglect and amygdala reactivity. American Journal of Psychiatry, 169, 515-522.
- Bogdan R, Santesso DL, Fagerness J, Perlis RH & Pizzagalli DA. (2011). Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. Journal of Neuroscience, 31, 13110-13117.
- Bogdan R & Pizzagalli DA. (2006). Acute stress reduces reward responsiveness: Implications for depression. Biological Psychiatry, 60, 1147-1154.
- Abnormal Psychology: The Major Mental Disorders (Psychology 354)
- Genes, Brain, and Behavior: Pathways to Psychopathology (Psychology 4745)